You will be asked to enter your domain name, the email address you want, and a password.
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sudo management/whats_next.py
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This will tell you what to do next. Then visit https://yourdomain.com/mail to start emailing. Or use any mail program with IMAPS (port 993) and SMTP with STARTTLS (port 587). Your username is your complete email address.
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Note: This is a work in progress. I work on Mail-in-a-Box in my limited free time. Your mileage may vary.